Funds raised will be used to support translational research [the use of basic research techniques to solve clinical problems] in the field of vascular anomalies, in particular arteriovenous malformations. Money is needed to pay for the tests that analyze proteins produced by AVMs [mass spectroscopy], develop animal models to test new drugs for AVM, develop and test quantitative imaging tests for patients with AVM, and to pay the salary of a postdoctoral fellow to carry out the basic science needed to solve these problems.
The foundation has raised over $100,000 toward this research, but we still need to raise more.
Dr. Ramchandran and his team, in collaboration with Dr. Burrows, are currently conducting AVM research at the Medical College of Wisconsin using zebrafish. Zebrafish share the same genes that humans have, and their blood vessels are easier to access thereby making them a suitable model for AVM studies. The ultimate goal of the research is to find a treatment for people with AVMs. They are currently identifying biomarkers for AVMs that will hopefully correlate genetic defects with types of AVM – a task that will help physicians more easily determine what type of AVM a patient has.
Current Vascular Anomalies Research at the Children’s Hospital of Wisconsin and the Medical College of Wisconsin
R. Ramchandran lab
Pediatric Interventional Radiology