AVM Research

AVM Research
AVM Research

Funds raised will be used to support translational research [the use of basic research techniques to solve clinical problems] in the field of vascular anomalies, in particular arteriovenous malformations. Money is needed to pay for the tests that analyze proteins produced by AVMs [mass spectroscopy], develop animal models to test new drugs for AVM, develop and test quantitative imaging tests for patients with AVM, and to pay the salary of a postdoctoral fellow to carry out the basic science needed to solve these problems.

The foundation has raised over $100,000 toward this research, but we still need to raise more.

Dr. Ramchandran and his team, in collaboration with Dr. Burrows, are currently conducting AVM research at the Medical College of Wisconsin using zebrafish. Zebrafish share the same genes that humans have, and their blood vessels are easier to access thereby making them a suitable model for AVM studies. The ultimate goal of the research is to find a treatment for people with AVMs. They are currently identifying biomarkers for AVMs that will hopefully correlate genetic defects with types of AVM – a task that will help physicians more easily determine what type of AVM a patient has. 

Current Vascular Anomalies Research at the Children’s Hospital of Wisconsin and the Medical College of Wisconsin

R. Ramchandran lab

  • Investigating the role for Delta-like 4 antisense long non-coding RNA in the pathogenesis of vascular anomalies
  • Investigating the role of DUSP 5 in the pathogenesis of vascular anomalies
  • Screening for drugs (FDA-approved & small molecules) that target the DUSP5 signaling pathway
  • Proteomic analyses in patients undergoing treatment for vascular anomalies
  • Culture and functional analysis of lymphatic endothelial cells from patients with cystic lymphatic malformations


Pediatric Interventional Radiology

  • Imaging response of patients undergoing sclerotherapy of cystic lymphatic malformations
  • Step table venography in the evaluation and treatment of venous anomalies of the lower extremity
  • Proteomic analysis of patients undergoing treatment for vascular anomalies
  • Objective imaging measurement of AVM flow
  • Random monoallelic expression in Patients with RASA1 mutation



  • Hemangioma​
  • PHACE syndrome
    • International registry
    • Predictors of stroke in patients with PHACE syndrome
    • Dental abnormalities in PHACE syndrome
    • Gene discovery in PHACE syndrome
  • Safety of topical timolol for infantile hemangioma​
  • Pharmacokinetics for topical timolol for infantile hemangioma
  • Vascular Malformations
    • Overgrowth in patients with vascular anomalies; a multicenter genomic study


Pediatric Pathology

  • Lymphatic Vessel Abnormalities in CM-AVM​
  • GNAQ mutations in Sturge-Weber syndrome and port-wine stains
  • Pathogenesis of infantile hemangioma